通过将无活性蒽环类药物与聚合物偶联获得的新型细胞毒性模式。
Novel mode of cytotoxicity obtained by coupling inactive anthracycline to a polymer.
作者信息
Rogers K E, Tökés Z A
出版信息
Biochem Pharmacol. 1984 Feb 15;33(4):605-8. doi: 10.1016/0006-2952(84)90315-0.
PMID:6422950
Abstract
The inactive anthracycline analog 4-demethoxy-7,9-di-epi-daunorubicin was covalently coupled to polyglutaraldehyde microspheres. The polymer-bound analog acquired significant cytostatic activity as evaluated with doxorubicin resistant and sensitive murine L1210 leukemia cells. A suggested multiple membrane interaction at the cell surface may represent a novel mechanism of cytotoxicity.
摘要
非活性蒽环类类似物4-去甲氧基-7,9-二表柔红霉素与聚戊二醛微球共价偶联。用对多柔比星耐药和敏感的小鼠L1210白血病细胞评估，与聚合物结合的类似物具有显著的细胞生长抑制活性。一种推测的细胞表面多重膜相互作用可能代表一种新的细胞毒性机制。
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