钙拮抗剂与内分泌状态：口服维拉帕米对垂体 - 睾丸及垂体 - 甲状腺功能无影响。
Calcium antagonists and endocrine status: lack of effect of oral verapamil on pituitary-testicular and pituitary-thyroid function.
作者信息
Semple C G, Thomson J A, Beastall G H, Lorimer A R
出版信息
Br J Clin Pharmacol. 1984 Feb;17(2):179-82. doi: 10.1111/j.1365-2125.1984.tb02336.x.
Abstract
Calcium ions seem to be essential for the release of many hormones. The calcium antagonist verapamil which is used as an anti-arrhythmic and anti-anginal agent has an inhibitory effect on the release of follicle stimulating hormone (FSH), luteinising hormone (LH), and thyrotrophin stimulating hormone (TSH) when given as an intravenous infusion to normal volunteers. As verapamil is usually given orally we studied pituitary-testicular and pituitary-thyroid function before and after completing a 4-week course of oral verapamil. The oral preparation did not have any significant effect on the endocrine parameters studied.
摘要
钙离子似乎对许多激素的释放至关重要。用作抗心律失常和抗心绞痛药物的钙拮抗剂维拉帕米，在给正常志愿者静脉输注时，对促卵泡激素（FSH）、促黄体生成素（LH）和促甲状腺激素（TSH）的释放有抑制作用。由于维拉帕米通常是口服给药，我们在完成为期4周的口服维拉帕米疗程前后，研究了垂体 - 睾丸和垂体 - 甲状腺功能。口服制剂对所研究的内分泌参数没有任何显著影响。
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