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钙拮抗剂与内分泌状态：口服维拉帕米对垂体 - 睾丸及垂体 - 甲状腺功能无影响。

Calcium antagonists and endocrine status: lack of effect of oral verapamil on pituitary-testicular and pituitary-thyroid function.

作者信息

Semple C G, Thomson J A, Beastall G H, Lorimer A R

出版信息

Br J Clin Pharmacol. 1984 Feb;17(2):179-82. doi: 10.1111/j.1365-2125.1984.tb02336.x.

DOI:10.1111/j.1365-2125.1984.tb02336.x
PMID:6422973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1463315/
Abstract

Calcium ions seem to be essential for the release of many hormones. The calcium antagonist verapamil which is used as an anti-arrhythmic and anti-anginal agent has an inhibitory effect on the release of follicle stimulating hormone (FSH), luteinising hormone (LH), and thyrotrophin stimulating hormone (TSH) when given as an intravenous infusion to normal volunteers. As verapamil is usually given orally we studied pituitary-testicular and pituitary-thyroid function before and after completing a 4-week course of oral verapamil. The oral preparation did not have any significant effect on the endocrine parameters studied.

摘要

钙离子似乎对许多激素的释放至关重要。用作抗心律失常和抗心绞痛药物的钙拮抗剂维拉帕米，在给正常志愿者静脉输注时，对促卵泡激素（FSH）、促黄体生成素（LH）和促甲状腺激素（TSH）的释放有抑制作用。由于维拉帕米通常是口服给药，我们在完成为期4周的口服维拉帕米疗程前后，研究了垂体 - 睾丸和垂体 - 甲状腺功能。口服制剂对所研究的内分泌参数没有任何显著影响。

相似文献

1
Calcium antagonists and endocrine status: lack of effect of oral verapamil on pituitary-testicular and pituitary-thyroid function.钙拮抗剂与内分泌状态：口服维拉帕米对垂体 - 睾丸及垂体 - 甲状腺功能无影响。
Br J Clin Pharmacol. 1984 Feb;17(2):179-82. doi: 10.1111/j.1365-2125.1984.tb02336.x.
2
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2
Nifedipine and endocrine status in diabetic patients.硝苯地平与糖尿病患者的内分泌状态
Br J Clin Pharmacol. 1984 Oct;18(4):648-50. doi: 10.1111/j.1365-2125.1984.tb02523.x.

本文引用的文献

1
Rapid high-performance liquid chromatographic method for the measurement of verapamil and norverapamil in blood plasma or serum.快速高效液相色谱法测定血浆或血清中的维拉帕米和去甲维拉帕米。
J Chromatogr. 1981 Nov 20;218:621-9. doi: 10.1016/s0021-9673(00)82087-7.
2
Verapamil-induced hyperprolactinemia and galactorrhea.
Ann Intern Med. 1981 Jul;95(1):66-7. doi: 10.7326/0003-4819-95-1-66.
3
Oral verapamil does not affect glucose tolerance in non-diabetics.口服维拉帕米不影响非糖尿病患者的糖耐量。
Br J Clin Pharmacol. 1983 May;15(5):570-1. doi: 10.1111/j.1365-2125.1983.tb02094.x.
4
Hyperglycaemic effect of nifedipine.硝苯地平的高血糖效应。
Br Med J (Clin Res Ed). 1981 Jul 4;283(6283):19-20. doi: 10.1136/bmj.283.6283.19.
5
Calcium antagonists and hormone release. II. Effects of verapamil on basal, gonadotropin-releasing hormone- and thyrotropin-releasing hormone-induced pituitary hormone release in normal subjects.钙拮抗剂与激素释放。II. 维拉帕米对正常受试者基础状态下、促性腺激素释放激素及促甲状腺激素释放激素诱导的垂体激素释放的影响。
J Clin Endocrinol Metab. 1980 Oct;51(4):749-53. doi: 10.1210/jcem-51-4-749.
6
Calcium antagonists and hormone release: effect of nifedipine on luteinizing hormone-releasing hormone and thyrotropin-releasing hormone-induced pituitary hormone release.钙拮抗剂与激素释放：硝苯地平对促黄体生成素释放激素和促甲状腺激素释放激素诱导的垂体激素释放的影响。
J Clin Endocrinol Metab. 1983 Feb;56(2):401-4. doi: 10.1210/jcem-56-2-401.
7
Calcium channel blockers for cardiovascular disorders.用于心血管疾病的钙通道阻滞剂。
Arch Intern Med. 1982 Mar;142(3):452-5.
8
Calcium antagonists and hormone release. I. Effects of verapamil on insulin release in normal subjects and patients with islet-cell tumor.钙拮抗剂与激素释放。I. 维拉帕米对正常受试者及胰岛细胞瘤患者胰岛素释放的影响。
Metabolism. 1980 Jul;29(7):599-604. doi: 10.1016/0026-0495(80)90103-1.
9
Steroidogenic action of calcium ions in isolated adrenocortical cells.钙离子在分离的肾上腺皮质细胞中的类固醇生成作用。
Biochem J. 1980 Feb 15;186(2):391-7. doi: 10.1042/bj1860391.
10
Verapamil and norverapamil plasma concentrations during long-term therapy in patients with hypertrophic obstructive cardiomyopathy.肥厚性梗阻性心肌病患者长期治疗期间维拉帕米和去甲维拉帕米的血浆浓度。
J Cardiovasc Pharmacol. 1980 Jan-Feb;2(1):17-23. doi: 10.1097/00005344-198001000-00003.