Nielsen-Kudsk J E, Bartels P D
Department of Clinical Chemistry, Randers General Hospital, County of Aarhus, Denmark.
Thyroidology. 1990 Apr;2(1):13-6.
We have evaluated the effects of oral administration of the calcium blocker verapamil on the pituitary secretion of TSH. Verapamil was administered 120 mg tid to 6 healthy volunteers. Plasma TSH was measured with an ultrasensitive immunoradiometric assay. TSH secretion was assessed by a 24-hour profile of unstimulated plasma concentrations and by the effect of TRH stimulation before and after 7 days of verapamil administration. No effects of verapamil was found on either basal or stimulated secretion of TSH.
我们评估了口服钙通道阻滞剂维拉帕米对垂体促甲状腺激素（TSH）分泌的影响。对6名健康志愿者给予维拉帕米，剂量为每日3次，每次120mg。采用超灵敏免疫放射分析法测定血浆TSH。通过24小时未刺激血浆浓度曲线以及在维拉帕米给药7天前后促甲状腺激素释放激素（TRH）刺激的效果来评估TSH分泌。未发现维拉帕米对TSH的基础分泌或刺激分泌有任何影响。
