Rouveix B, Lassoued K, Vittecoq D, Regnier B
Br Med J (Clin Res Ed). 1983 Dec 17;287(6408):1832-4. doi: 10.1136/bmj.287.6408.1832.
Neutropenia developed in 13 patients during treatment with beta lactamines. The time of onset ranged from eight to 27 days after beginning treatment and occurred with doses as low as 40 mg/24 hours. Concomitant symptoms were eosinophilia, rashes, and fever. Leucoagglutinins were detected in eight out of nine patients by the microleucoagglutination technique. Clinical and serological findings suggested that neutrophils become sensitised as a result of absorption on the cell membrane of drug-antibody immune complexes. An immune mediated pathogenesis for neutropenia induced by beta lactamine seems highly probable.
13例患者在使用β-内酰胺类药物治疗期间出现了中性粒细胞减少症。发病时间在开始治疗后的8至27天之间，最低剂量为40毫克/24小时时也会出现。伴随症状有嗜酸性粒细胞增多、皮疹和发热。通过微量白细胞凝集技术在9例患者中的8例检测到白细胞凝集素。临床和血清学结果表明，中性粒细胞因药物-抗体免疫复合物在细胞膜上的吸附而致敏。β-内酰胺类药物诱导的中性粒细胞减少症很可能是由免疫介导的发病机制引起的。
