Yajnik C S, Smith R F, Hockaday T D, Ward N I
Br Med J (Clin Res Ed). 1984 Apr 7;288(6423):1032-4. doi: 10.1136/bmj.288.6423.1032.
Fasting plasma concentrations of magnesium were measured by neutron activation analysis in 30 non-diabetics and 87 diabetics (55 non-insulin-treated, 32 insulin treated). Plasma concentrations of magnesium were lowest in the insulin treated group (mean 0.84 (SEM 0.01) mmol/1; 2.0 (0.02) mg/100 ml), intermediate in the non-diabetics (mean 0.89 (SEM 0.01) mmol/1; 2.2 (0.02) mg/100 ml), and highest in the non-insulin-treated diabetics (mean 0.95 (SEM 0.02) mmol/1; 2.3 (0.05) mg/100 ml). In all diabetics plasma magnesium concentrations were inversely related to plasma glucose values (rs = -0.33; p less than 0.01) and in non-insulin-treated patients to plasma insulin concentrations (rs = -0.28; p less than 0.05), the former confirming previous observations. In 67 of the diabetics the KG constant for disposal rate of glucose during a standard intravenous glucose tolerance test was directly related to fasting plasma magnesium concentrations, and this relation persisted after controlling for age, sex, body mass index, type of treatment, and glucose and insulin values. This direct relation of plasma magnesium concentration with glucose disposal was unexplained by its influence on insulin secretion but was related to insulin sensitivity; hence magnesium may be an important determinant of insulin sensitivity in maturity onset diabetes.
采用中子活化分析法测定了30名非糖尿病患者和87名糖尿病患者（55名非胰岛素治疗患者，32名胰岛素治疗患者）的空腹血浆镁浓度。胰岛素治疗组的血浆镁浓度最低（平均0.84（标准误0.01）mmol/L；2.0（0.02）mg/100ml），非糖尿病患者居中（平均0.89（标准误0.01）mmol/L；2.2（0.02）mg/100ml），非胰岛素治疗的糖尿病患者最高（平均0.95（标准误0.02）mmol/L；2.3（0.05）mg/100ml）。在所有糖尿病患者中，血浆镁浓度与血浆葡萄糖值呈负相关（rs = -0.33；p<0.01），在非胰岛素治疗患者中与血浆胰岛素浓度呈负相关（rs = -0.28；p<0.05），前者证实了先前的观察结果。在67名糖尿病患者中，标准静脉葡萄糖耐量试验期间葡萄糖处置率的KG常数与空腹血浆镁浓度直接相关，在控制年龄、性别、体重指数、治疗类型以及葡萄糖和胰岛素值后，这种关系仍然存在。血浆镁浓度与葡萄糖处置之间的这种直接关系无法用其对胰岛素分泌的影响来解释，但与胰岛素敏感性有关；因此，镁可能是成年型糖尿病中胰岛素敏感性的重要决定因素。
