Bauer F C, Nilsson O S, Tornkvist H, Lindholm T C, Lindholm T S
Clin Orthop Relat Res. 1984 May(185):266-9.
Implants of demineralized allogeneic bone were investigated to determine the effects of ethane-1-hydroxy-1,1-diphosphonate (EHDP) on the osteoinductive effect of bone matrix. Implants of matrix prepared from bones of rats treated by EHDP (20 mg/kg/day) produced 40% less ash than implants of normal bone matrix. These results indicate that EHDP not only interferes with mineralization but also has a direct effect on protein metabolism of bone cells.
对脱矿同种异体骨植入物进行了研究，以确定乙烷-1-羟基-1,1-二膦酸盐（EHDP）对骨基质骨诱导作用的影响。用EHDP（20毫克/千克/天）处理的大鼠骨骼制备的基质植入物产生的灰分比正常骨基质植入物少40%。这些结果表明，EHDP不仅干扰矿化，而且对骨细胞的蛋白质代谢有直接影响。
