• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

分离的肝细胞在叔丁基过氧化氢代谢过程中胞质钙离子浓度的升高涉及NADPH氧化和细胞内钙储存的动员。

Increase in cytosolic Ca2+ concentration during t-butyl hydroperoxide metabolism by isolated hepatocytes involves NADPH oxidation and mobilization of intracellular Ca2+ stores.

作者信息

Bellomo G, Thor H, Orrenius S

出版信息

FEBS Lett. 1984 Mar 12;168(1):38-42. doi: 10.1016/0014-5793(84)80202-1.

DOI:10.1016/0014-5793(84)80202-1
PMID:6423407
Abstract

Activation of phosphorylase a in hepatocytes incubated with t-butyl hydroperoxide indicates that hydroperoxide metabolism is associated with an increase in cytosolic free Ca2+ concentration which appears to be mediated by NADPH oxidation and to involve mobilization of intracellular Ca2+ stores.

摘要

在用叔丁基过氧化氢孵育的肝细胞中，磷酸化酶a的激活表明过氧化氢代谢与胞质游离Ca2+浓度的增加有关，这似乎是由NADPH氧化介导的，并且涉及细胞内Ca2+储存的动员。

相似文献

1
Increase in cytosolic Ca2+ concentration during t-butyl hydroperoxide metabolism by isolated hepatocytes involves NADPH oxidation and mobilization of intracellular Ca2+ stores.分离的肝细胞在叔丁基过氧化氢代谢过程中胞质钙离子浓度的升高涉及NADPH氧化和细胞内钙储存的动员。
FEBS Lett. 1984 Mar 12;168(1):38-42. doi: 10.1016/0014-5793(84)80202-1.
2
Protection of rat hepatocytes from tert-butyl hydroperoxide-induced injury by catechol.邻苯二酚对叔丁基过氧化氢诱导的大鼠肝细胞损伤的保护作用
Toxicol Appl Pharmacol. 1986 Jul;84(3):607-16. doi: 10.1016/0041-008x(86)90267-x.
3
Regulation of intracellular calcium compartmentation: studies with isolated hepatocytes and t-butyl hydroperoxide.细胞内钙区隔化的调节：对分离的肝细胞和叔丁基过氧化氢的研究
Proc Natl Acad Sci U S A. 1982 Nov;79(22):6842-6. doi: 10.1073/pnas.79.22.6842.
4
Potentiation of oxidative cell injury in hepatocytes which have accumulated Ca2+.在已积累钙离子的肝细胞中氧化细胞损伤的增强。
J Biol Chem. 1984 May 25;259(10):6612-5.
5
Pyridine-nucleotide oxidation, Ca2+ cycling and membrane damage during tert-butyl hydroperoxide metabolism by rat-liver mitochondria.叔丁基过氧化氢在大鼠肝脏线粒体中代谢时的吡啶核苷酸氧化、钙离子循环及膜损伤
Eur J Biochem. 1984 Apr 2;140(1):1-6. doi: 10.1111/j.1432-1033.1984.tb08058.x.
6
Correlation between cytosolic Ca2+ concentration and cytotoxicity in hepatocytes exposed to oxidative stress.暴露于氧化应激的肝细胞中胞质钙离子浓度与细胞毒性之间的相关性。
Toxicology. 1988 Nov 14;52(1-2):55-63. doi: 10.1016/0300-483x(88)90196-5.
7
Alterations in intracellular calcium compartmentation following inhibition of calcium efflux from isolated hepatocytes.抑制离体肝细胞钙外流后细胞内钙分隔的改变
Eur J Biochem. 1984 Oct 1;144(1):19-23. doi: 10.1111/j.1432-1033.1984.tb08425.x.
8
Biochemical changes in isolated hepatocytes exposed to tert-butyl hydroperoxide. Implications for its cytotoxicity.暴露于叔丁基过氧化氢的离体肝细胞中的生化变化。对其细胞毒性的影响。
Cell Biol Toxicol. 1991 Apr;7(2):129-43. doi: 10.1007/BF00122827.
9
Increases in cytosolic calcium ion concentration can be dissociated from the killing of cultured hepatocytes by tert-butyl hydroperoxide.胞质钙离子浓度的升高可能与叔丁基过氧化氢对培养肝细胞的杀伤作用无关。
J Biol Chem. 1991 Jan 15;266(2):717-22.
10
Oscillatory cytosolic calcium waves independent of stimulated inositol 1,4,5-trisphosphate formation in hepatocytes.肝细胞中独立于刺激的肌醇1,4,5-三磷酸形成的振荡性胞质钙波
J Biol Chem. 1991 Jul 5;266(19):12272-82.

引用本文的文献

1
Protective effect of black garlic extracts on tert-Butyl hydroperoxide-induced injury in hepatocytes via a c-Jun N-terminal kinase-dependent mechanism.黑蒜提取物通过c-Jun氨基末端激酶依赖性机制对叔丁基过氧化氢诱导的肝细胞损伤的保护作用。
Exp Ther Med. 2018 Mar;15(3):2468-2474. doi: 10.3892/etm.2018.5719. Epub 2018 Jan 8.
2
Activation of CaMKIIγ potentiates T-cell acute lymphoblastic leukemia leukemogenesis via phosphorylating FOXO3a.CaMKIIγ的激活通过磷酸化FOXO3a增强T细胞急性淋巴细胞白血病的白血病发生。
Oncotarget. 2017 Aug 24;8(43):75050-75064. doi: 10.18632/oncotarget.20504. eCollection 2017 Sep 26.
3
Effect of Ca2+ channel blockers, external Ca2+ and phospholipase A2 inhibitors on t-butylhydroperoxide-induced lipid peroxidation and toxicity in rat liver slices.
钙离子通道阻滞剂、细胞外钙离子及磷脂酶A2抑制剂对叔丁基过氧化氢诱导的大鼠肝切片脂质过氧化及毒性的影响。
Korean J Intern Med. 1997 Jun;12(2):193-200. doi: 10.3904/kjim.1997.12.2.193.
4
Cytoprotective and antioxidant effects of boldine on tert-butyl hydroperoxide-induced damage to isolated hepatocytes.波耳定碱对叔丁基过氧化氢诱导的离体肝细胞损伤的细胞保护和抗氧化作用。
Cell Biol Toxicol. 1996 Apr;12(2):89-100. doi: 10.1007/BF00143359.
5
Ca-efflux, from direct membrane injury by CCl4, is elicited by amphiphilic vehicles in vitro.四氯化碳对细胞膜的直接损伤所引发的钙外流，在体外可由两亲性载体诱导产生。
Experientia. 1993 Oct 15;49(10):854-8. doi: 10.1007/BF01952597.
6
Mechanisms of cell injury by activated oxygen species.活性氧导致细胞损伤的机制。
Environ Health Perspect. 1994 Dec;102 Suppl 10(Suppl 10):17-24. doi: 10.1289/ehp.94102s1017.
7
Detection of peroxyl and alkoxyl radicals produced by reaction of hydroperoxides with rat liver microsomal fractions.氢过氧化物与大鼠肝微粒体组分反应产生的过氧自由基和烷氧自由基的检测。
Biochem J. 1989 Jan 15;257(2):603-6. doi: 10.1042/bj2570603.
8
Impact of halogenated compounds on calcium homeostasis in hepatocytes.卤代化合物对肝细胞钙稳态的影响。
Environ Health Perspect. 1990 Mar;84:149-53. doi: 10.1289/ehp.9084149.
9
The role of calcium ions in toxic cell injury.钙离子在毒性细胞损伤中的作用。
Environ Health Perspect. 1990 Mar;84:107-11. doi: 10.1289/ehp.9084107.
10
Biochemical changes in isolated hepatocytes exposed to tert-butyl hydroperoxide. Implications for its cytotoxicity.暴露于叔丁基过氧化氢的离体肝细胞中的生化变化。对其细胞毒性的影响。
Cell Biol Toxicol. 1991 Apr;7(2):129-43. doi: 10.1007/BF00122827.