T cell antigens and MHC determinants on rabbit granulocytes.

A cell preparation, consisting of 90% granulocytes (polymorphonuclear leukocytes), can be obtained from the rabbit peritoneal cavity. These cells have some membrane antigens, similar to those characteristic of thymus cells (T1, T2), but they do not have the thymus antigen, RTLA. Unlike thymus cells, many polymorphonuclear leukocytes have Ia antigen, in their membranes. Heterogeneity of the cell population is indicated by differences in the number of cells affected by complement-mediated cytotoxic cell-kill with monoclonal antibodies, directed against T1 and T2 and with polyclonal antibodies directed against Ia.