Vanderhoof J A, Grandjean C J, Burkley K T, Antonson D L
J Pediatr Gastroenterol Nutr. 1984 Mar;3(2):262-7. doi: 10.1097/00005176-198403000-00017.
Little is known concerning the effects of elemental diets on bowel adaptation following massive resection. Fourteen of 28 Sprague-Dawley rats (40-45 g) were subjected to a 60% jejunoileal resection. Seven of the resected animals and seven sham-operated controls were then placed on a diet containing all protein in the form of casein hydrolysate. The remaining seven resected animals and seven sham-operated controls were placed on a comparable diet in which all the protein was casein. Each control animal was paired with a resected animal. After 2 weeks, unidirectional glucose and leucine transport was determined from intestinal sacs made from the proximal 3 cm and distal 3 cm of the remaining bowel. The midportion was used for the determination of mucosal weight and protein and sucrase content. When expressed as a percent increase over control values per centimeter of bowel, only sucrase levels were significantly elevated in the distal bowel in casein hydrolysate-versus casein-fed animals. The mucosal protein level, mucosal weight, and glucose uptake did not differ from control values when expressed as a percent change. Leucine uptake was significantly decreased in casein hydrolysate-fed animals when compared to that in casein-fed animals in both the proximal and distal bowel, again when expressed as a percent change from the control values. The administration of protein in the form of casein hydrolysate following massive bowel resection does not adversely affect mucosal hyperplasia occurring after resection but may have an adverse effect on the enhancement of amino acid absorption.
关于要素饮食对大面积切除术后肠道适应性的影响，目前所知甚少。28只体重40 - 45克的斯普拉格 - 道利大鼠中，14只接受了60%空肠回肠切除术。然后，将7只切除手术的动物和7只假手术对照组动物置于一种饮食中，该饮食中所有蛋白质均为酪蛋白水解物形式。其余7只切除手术的动物和7只假手术对照组动物则置于一种类似的饮食中，其中所有蛋白质均为酪蛋白。每只对照动物与一只切除手术的动物配对。2周后，从剩余肠道近端3厘米和远端3厘米制成的肠囊中测定单向葡萄糖和亮氨酸转运。中间部分用于测定黏膜重量、蛋白质和蔗糖酶含量。当以每厘米肠道相对于对照值的百分比增加来表示时，在酪蛋白水解物喂养组与酪蛋白喂养组动物中，仅远端肠道的蔗糖酶水平显著升高。当以百分比变化表示时，黏膜蛋白水平、黏膜重量和葡萄糖摄取与对照值无差异。与酪蛋白喂养组动物相比，酪蛋白水解物喂养组动物在近端和远端肠道的亮氨酸摄取，同样以相对于对照值的百分比变化表示时，显著降低。大面积肠道切除术后给予酪蛋白水解物形式的蛋白质不会对切除术后发生黏膜增生产生不利影响，但可能对氨基酸吸收的增强有不利影响。
