Bíró J, Ritzén E M, Hall K, Eneroth P
J Steroid Biochem. 1984 Jan;20(1):343-5. doi: 10.1016/0022-4731(84)90230-9.
Plasma concentration and anterior pituitary content of growth hormone (rGH), thyroid stimulating hormone (rTSH), prolactin, follicle stimulating hormone (rFSH), luteinizing hormone (rLH) as well as the plasma concentrations of triiodothyronine (T3), thyroxine (T4), corticosterone and immunoreactive somatomedin A (SM-A) have been determined in intact, ovariectomized or ovo-hysterectomized rats with and without treatment with steroid-free uterine extracts. The endocrine organs were weighed. Two weeks after hysterectomy the body weight was decreased, the weight of adrenals was increased, the plasma GH concentrations increased and the plasma TSH and T3 concentrations were decreased compared to the sham operated controls. Treatment with steroid-free uterine extracts had opposite effects; furthermore, a reduction of pituitary FSH, GH and prolactin content was observed. Plasma immunoreactive SM-A concentrations were not significantly influenced by this treatment, but there was a positive correlation between the body weight and SM-A and a negative correlation between the plasma GH and plasma SM-A concentrations regarding the individual values of hysterectomized, uterine-extract-treated and ovariectomized animals. The results suggests that uterine factors can influence the synthesis and release of several hormones and the weight of some endocrine organs in adult, nonpregnant rats.
在完整、去卵巢或去卵巢子宫切除的大鼠中，测定了生长激素（rGH）、促甲状腺激素（rTSH）、催乳素、促卵泡激素（rFSH）、黄体生成素（rLH）的血浆浓度和垂体前叶含量，以及三碘甲状腺原氨酸（T3）、甲状腺素（T4）、皮质酮和免疫反应性生长调节素A（SM-A）的血浆浓度。对内分泌器官进行称重。与假手术对照组相比，子宫切除术后两周，体重下降，肾上腺重量增加，血浆GH浓度升高，血浆TSH和T3浓度降低。用无类固醇子宫提取物治疗有相反的效果；此外，观察到垂体FSH、GH和催乳素含量减少。血浆免疫反应性SM-A浓度不受该治疗的显著影响，但就子宫切除、子宫提取物治疗和去卵巢动物的个体值而言，体重与SM-A之间呈正相关，血浆GH与血浆SM-A浓度之间呈负相关。结果表明，子宫因素可影响成年非孕大鼠几种激素的合成和释放以及一些内分泌器官的重量。
