Biro J C, Eneroth P
J Endocrinol. 1987 Apr;113(1):21-6. doi: 10.1677/joe.0.1130021.
The effects of hysterectomy and ovariectomy on plasma concentrations of GH, somatomedin A, TSH and thyroxine (T4) were studied in developing rats. Four groups of 24-day-old rats were ovariectomized, ovohysterectomized, hysterectomized or sham-operated. Their weights, lengths and plasma hormone concentrations were measured at 26, 43, 64, 78 and 92 days of age to investigate pre- and postpubertal differences caused by the uterus or ovaries. Plasma concentrations of the hormones examined showed a successive rise with time, but GH and somatomedin A concentrations rose mainly after the opening of the vagina (days 50-55). Higher GH and somatomedin A concentrations were found in the plasma of ovariectomized animals than in ovohysterectomized controls before puberty (GH: 260-300%, P less than 0.01; somatomedin A: 25-30%, P less than 0.05). Ovariectomized animals weighed more than ovohysterectomized females after puberty (4.5-6%, P less than 0.01). This indicated that the uterus exerted a stimulatory effect on GH-somatomedin A regulation and body weight gain in the absence of the ovaries. Significantly lower plasma somatomedin A (but not GH) concentrations were found in hysterectomized and sham-operated animals than in their respective controls after puberty (30-39%, P less than 0.01) and their final body weight was lower (22-26%, P less than 0.001). There were no consecutive uterus- or ovary-related changes in plasma TSH and T4 levels. It was concluded that both the uterus and ovaries had significant as well as opposite effects on somatomedin A and body weight with the effects of the ovaries being greater than those of the uterus.
在发育中的大鼠身上研究了子宫切除术和卵巢切除术对血浆中生长激素（GH）、生长调节素A、促甲状腺激素（TSH）和甲状腺素（T4）浓度的影响。将四组24日龄的大鼠分别进行卵巢切除、卵巢子宫切除、子宫切除或假手术。在26、43、64、78和92日龄时测量它们的体重、体长和血浆激素浓度，以研究子宫或卵巢引起的青春期前和青春期后的差异。所检测激素的血浆浓度随时间呈连续上升，但GH和生长调节素A浓度主要在阴道开口后（第50 - 55天）上升。在青春期前，卵巢切除动物血浆中的GH和生长调节素A浓度高于卵巢子宫切除对照动物（GH：260 - 300%，P < 0.01；生长调节素A：25 - 30%，P < 0.05）。青春期后，卵巢切除动物比卵巢子宫切除的雌性动物体重更重（4.5 - 6%，P < 0.01）。这表明在没有卵巢的情况下，子宫对GH - 生长调节素A调节和体重增加具有刺激作用。青春期后，子宫切除和假手术动物血浆中的生长调节素A（但不是GH）浓度显著低于各自的对照动物（30 - 39%，P < 0.01），且它们的最终体重更低（22 - 26%，P < 0.001）。血浆TSH和T4水平没有与子宫或卵巢相关的连续变化。得出的结论是，子宫和卵巢对生长调节素A和体重都有显著且相反的影响，卵巢的影响大于子宫。
