Mathog D, Hochstrasser M, Gruenbaum Y, Saumweber H, Sedat J
Nature. 1984;308(5958):414-21. doi: 10.1038/308414a0.
A computer-based system for recording and analysing light microscope images, combined with classical cytogenetic analysis, has revealed the spatial organization of the giant chromosomes of Drosophila salivary gland cells. Each polytene chromosome arm folds up in a characteristic way, contacts the nuclear surface at specific sites and is topologically isolated from all other arms.
一个用于记录和分析光学显微镜图像的计算机系统，结合经典细胞遗传学分析，揭示了果蝇唾液腺细胞巨大染色体的空间组织。每个多线染色体臂以一种独特的方式折叠，在特定位置与核表面接触，并在拓扑结构上与所有其他臂隔离。
