Acocella G
Minerva Med. 1984 Mar 17;75(11):561-3.
The good results gotten employing short-term (6 months) medication regimes with rifampin, isoniazid and an initial supplement (2 months) of streptomycin and pyrazinamide, gave an impulse to pharmacodynamic research. Some recent studies divided bacterial population into four groups, according to bacterial growth time and they showed that rifampin, isoniazid and streptomycin act on mycobacterial groups continuously or intermittently growing. This fact confirms the validity of employed therapeutic regimens. An other paper considered the trend of hematic levels of streptomycin, isoniazid, rifampin and pyrazinamide. The results of this study showed that the variations observed in hematic peaks were independent from the administered doses and from the administration way. These researches help in solving the most important problems of present tubercular chemotherapy, such the use of a single drug or the therapy interruption.
采用利福平、异烟肼以及初始补充（2个月）链霉素和吡嗪酰胺的短期（6个月）药物治疗方案所取得的良好效果，推动了药效学研究。最近的一些研究根据细菌生长时间将细菌群体分为四组，结果表明利福平、异烟肼和链霉素作用于持续或间歇性生长的分枝杆菌群体。这一事实证实了所采用治疗方案的有效性。另一篇论文研究了链霉素、异烟肼、利福平和吡嗪酰胺的血药浓度变化趋势。该研究结果表明，观察到的血药峰浓度变化与给药剂量和给药方式无关。这些研究有助于解决当前结核病化疗中最重要的问题，比如单一药物的使用或治疗中断。
