呋喃妥因会损害人类细胞的DNA。
Nitrofurantoin damages DNA of human cells.
作者信息
Hirsch-Kauffmann M, Herrlich P, Schweiger M
出版信息
Klin Wochenschr. 1978 Apr 15;56(8):405-7. doi: 10.1007/BF01477295.
PMID:642414
Abstract
Nitrofurantoin causes damage to DNA of cultured diploid human fibroblasts. As a consequence DNA synthesis is blocked. The damage is removed by the normal enzymatic DNA repair system. Xeroderma pigmentosum fibroblasts which are defective in the excision endonuclease fail to repair nitrofurantoin-caused lesions.
摘要
呋喃妥因会对培养的二倍体人成纤维细胞的DNA造成损伤。结果，DNA合成被阻断。这种损伤可由正常的酶促DNA修复系统清除。在切除核酸内切酶方面存在缺陷的着色性干皮病成纤维细胞无法修复呋喃妥因引起的损伤。
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