着色性干皮病细胞的无细胞提取物中胸腺嘧啶二聚体切除缺陷。
Defective thymine dimer excision by cell-free extracts of xeroderma pigmentosum cells.
作者信息
Mortelmans K, Friedberg E C, Slor H, Thomas G, Cleaver J E
出版信息
Proc Natl Acad Sci U S A. 1976 Aug;73(8):2757-61. doi: 10.1073/pnas.73.8.2757.
Abstract
Crude extracts of normal human diploid fibroblasts and of human peripheral blood lymphocytes excise thymine dimers from purified ultraviolet-irradiated DNA, or from the DNA presumably present as chromatin in unfractionated cell-free preparations of cells that had been labeled with [3H]thymidine. Extracts of xeroderma pigmentosum cells from complementation groups A, C, and D also excise thymine dimers from purified DNA, but extracts of group A cells do not excise dimers from the DNA of radioactively labeled unfractionated cell-free preparations.
摘要
正常人二倍体成纤维细胞和人外周血淋巴细胞的粗提物能从纯化的紫外线照射过的DNA中，或从可能以染色质形式存在于用[3H]胸腺嘧啶核苷标记过的未分级无细胞细胞制剂中的DNA中切除胸腺嘧啶二聚体。来自互补组A、C和D的着色性干皮病细胞提取物也能从纯化的DNA中切除胸腺嘧啶二聚体，但A组细胞提取物不能从未分级放射性标记无细胞制剂的DNA中切除二聚体。
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Absence of excision of ultraviolet-induced cyclobutane dimers in xeroderma pigmentosum.着色性干皮病中紫外线诱导的环丁烷二聚体切除缺失。
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Evidence that xeroderma pigmentosum cells do not perform the first step in the repair of ultraviolet damage to their DNA.着色性干皮病细胞在修复其DNA紫外线损伤时不执行第一步的证据。
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Xeroderma pigmentosum: a human disease in which an initial stage of DNA repair is defective.着色性干皮病：一种人类疾病，其DNA修复的初始阶段存在缺陷。
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