Schwartz A M, Leonidas J C
Skeletal Radiol. 1984;11(1):13-6. doi: 10.1007/BF00361126.
Methotrexate osteopathy is an uncommon complication of long-term oral maintenance therapy for childhood neoplasms, most commonly acute lymphocytic leukemia. It is characterized by severe lower extremity pain and by osteoporosis particularly involving the lower extremities and thick dense provisional zones of calcification and growth arrest lines resembling scurvy. Fractures may occur. The appearance must be distinguished from recurrent or metastatic disease.
甲氨蝶呤性骨病是儿童肿瘤长期口服维持治疗（最常见于急性淋巴细胞白血病）的一种罕见并发症。其特征为严重的下肢疼痛以及骨质疏松，尤其累及下肢，还有增厚致密的钙化临时带和类似坏血病的生长停滞线。可能会发生骨折。其表现必须与复发或转移性疾病相鉴别。
