Carroll R R, Noyes W D, Rosse W F, Kitchens C S
Am J Med. 1984 Mar 30;76(3A):181-6. doi: 10.1016/0002-9343(84)90339-5.
Human immunoglobulin was administered intravenously to nine adult patients having severe chronic immune thrombocytopenia purpura. The response in three patients was an increase in the platelet count to greater than 50,000/mm3, a hemostatically adequate level. Response was associated with a pretreatment platelet-associated immunoglobulin level of more than 5,000 molecules per platelet, and successful treatment resulted in a decrease in that level. In those patients with pretreatment platelet-associated immunoglobulin levels less than 5,000 molecules per platelet, there was neither a significant decrease in that level nor an increase in their platelet count. Immunoglobulin infusion may prove useful for selected patients with severe chronic immune thrombocytopenia.
对9名患有严重慢性免疫性血小板减少性紫癜的成年患者静脉注射人免疫球蛋白。3名患者的反应是血小板计数增加至大于50,000/mm³，这是一个止血足够的水平。反应与预处理时血小板相关免疫球蛋白水平高于每血小板5,000个分子相关，成功治疗导致该水平降低。在那些预处理时血小板相关免疫球蛋白水平低于每血小板5,000个分子的患者中，该水平既没有显著降低，血小板计数也没有增加。免疫球蛋白输注可能对某些严重慢性免疫性血小板减少症患者有用。
