McConathy W J, Greenhalgh R M, Alaupovic P, Woolcock N E, Laing S P, Lund V, Lee E T, Taylor G W
Atherosclerosis. 1984 Mar;50(3):295-306. doi: 10.1016/0021-9150(84)90077-7.
The purpose of this study was to establish whether women with peripheral arterial disease can be distinguished from controls on the basis of plasma lipid and apolipoprotein profiles. One group of patients with peripheral arterial disease (n = 20) was characterized by a localized aortic stenosis referred to as the 'small aorta syndrome' (SAS). The other group of patients with peripheral arterial disease (n = 23) had a diffuse segmental pattern of stenoses referred to as the 'stenosing peripheral arterial disease' (SPAD). After correcting for the effects of age and body mass index, the SAS group had elevated plasma total cholesterol (TC) levels when compared to normal controls (P less than or equal to 0.008), while the SPAD group had triacylglycerol (TG) levels different from controls (P = 0.02). Both groups of patients were characterized by reduced levels of apolipoprotein A-I (P less than or equal to 0.04) and increased levels of apolipoprotein C-III (P less than or equal to 0.002). Apolipoproteins B and E were also elevated in both groups of patients but not significantly. Mutivariate analyses indicated that the A-I/C-III ratio correctly discriminated 97.8% of the SAS and the A-I/C-III ratio plus A-I discriminated 89.8% of the SPAD patient from the controls. In addition, multivariate analyses showed that the variables age, TC/Apo B, Apo B/C-III and TG/C-III discriminated SPAD from SAS patients with a correct classification of 93.2%. Results of this study showed that the measurement of apolipoproteins A-I, B and C-III in conjunction with TC and TG is of potential use for differentiating patients with peripheral arterial disease from normal controls as well as for distinguishing patients with SAS from those with SPAD. It seems that particular patterns of peripheral arterial disease in women may be associated with slightly different alterations in the plasma lipoprotein system.
本研究的目的是确定能否根据血浆脂质和载脂蛋白谱将外周动脉疾病女性患者与对照组区分开来。一组外周动脉疾病患者（n = 20）的特征是存在一种称为“小主动脉综合征”（SAS）的局限性主动脉狭窄。另一组外周动脉疾病患者（n = 23）具有称为“狭窄性外周动脉疾病”（SPAD）的弥漫性节段性狭窄模式。在校正年龄和体重指数的影响后，与正常对照组相比，SAS组的血浆总胆固醇（TC）水平升高（P≤0.008），而SPAD组的三酰甘油（TG）水平与对照组不同（P = 0.02）。两组患者的特征均为载脂蛋白A-I水平降低（P≤0.04）和载脂蛋白C-III水平升高（P≤0.002）。两组患者的载脂蛋白B和E也升高，但无统计学意义。多变量分析表明，A-I/C-III比值能正确区分97.8%的SAS患者，A-I/C-III比值加上A-I能将89.8%的SPAD患者与对照组区分开来。此外，多变量分析表明，年龄、TC/Apo B、Apo B/C-III和TG/C-III这些变量能将SPAD患者与SAS患者区分开来，正确分类率为93.2%。本研究结果表明，联合检测载脂蛋白A-I、B和C-III以及TC和TG，对于将外周动脉疾病患者与正常对照组区分开来以及将SAS患者与SPAD患者区分开来具有潜在用途。似乎女性外周动脉疾病的特定模式可能与血浆脂蛋白系统中略有不同的改变有关。
