Mills R P
Br Med J (Clin Res Ed). 1984 Apr 21;288(6425):1199-201. doi: 10.1136/bmj.288.6425.1199.
Questionnaires on antibiotic treatment of acute otitis media in children were sent to the general practitioners who make regular referrals to clinics in the King's College Hospital group. The most popular first choice of drug was amoxycillin (44%), but 37% of general practitioners said that they often used oral phenoxymethylpenicillin. This drug has relatively low activity against Haemophilus influenzae and many strains of Staphylococcus aureus. It is poorly absorbed from the stomach, does not penetrate the middle ear well, and its use may be one factor in the development of chronic middle ear effusions after acute otitis media. Sixty two per cent of the doctors who replied never treated acute otitis media with intramuscular antibiotics, but 57% used oral loading doses. Ninety seven per cent never treated their patients without antibiotics.
针对儿童急性中耳炎抗生素治疗情况的调查问卷被发送给了那些定期将患者转诊至国王学院医院集团所属诊所的全科医生。最常用的首选药物是阿莫西林（44%），但37%的全科医生表示他们经常使用口服青霉素V钾片。这种药物对流感嗜血杆菌和许多金黄色葡萄球菌菌株的活性相对较低。它从胃部吸收较差，不能很好地穿透中耳，其使用可能是急性中耳炎后慢性中耳积液形成的一个因素。62%回复问卷的医生从未用肌肉注射抗生素治疗急性中耳炎，但57%使用口服负荷剂量。97%的医生从未在没有使用抗生素的情况下治疗患者。
