Sharp P S, Foley K, Chahal P, Kohner E M
Clin Endocrinol (Oxf). 1984 Apr;20(4):497-501. doi: 10.1111/j.1365-2265.1984.tb03447.x.
Pituitary responsiveness to 44 amino acid human pancreatic growth hormone releasing factor was tested under conditions of euglycaemia and hyperglycaemia in six normal subjects. A 100 micrograms dose of growth hormone releasing factor was given at a fasting blood glucose of 5.1 +/- 0.4 mmols/l (mean +/- S.D.), and at a blood glucose level of 10.9 +/- 1.5. Under conditions of hyperglycaemia, the GH response to releasing factor was significantly depressed when compared to results obtained at fasting blood glucose (n = 6, t = 3.902, P = 0.0114). This is in keeping with the hypothesis that hyperglycaemia, mediated by the hypothalamus, causes decreased pituitary sensitivity to natural growth hormone releasing hormone.
在六名正常受试者中，在血糖正常和高血糖的情况下测试了垂体对44个氨基酸的人胰腺生长激素释放因子的反应性。在空腹血糖为5.1±0.4毫摩尔/升（平均值±标准差）以及血糖水平为10.9±1.5时，给予100微克剂量的生长激素释放因子。在高血糖情况下，与空腹血糖时获得的结果相比，生长激素释放因子引起的生长激素反应明显降低（n = 6，t = 3.902，P = 0.0114）。这与以下假设一致，即由下丘脑介导的高血糖会导致垂体对天然生长激素释放激素的敏感性降低。
