口服葡萄糖可抑制正常人体内由人胰腺生长激素释放因子1 - 44诱导的生长激素分泌。

Oral glucose inhibits growth hormone secretion induced by human pancreatic growth hormone releasing factor 1-44 in normal man.

作者信息

Davies R R, Turner S, Johnston D G

出版信息

Clin Endocrinol (Oxf). 1984 Oct;21(4):477-81. doi: 10.1111/j.1365-2265.1984.tb03235.x.

DOI:10.1111/j.1365-2265.1984.tb03235.x

Abstract

The interaction between the inhibitory effect on growth hormone secretion of a 75 g oral glucose load and the stimulatory effect of human pancreatic growth hormone releasing factor 1-44 (hpGRF 1-44, 10 micrograms i.v.) has been studied in six normal subjects. hpGRF 1-44 alone induced a rise in growth hormone concentrations (maximum mean +/- SEM, 16.5 +/- 1.7 mU/l 15 min after injection) while growth hormone levels were suppressed by oral glucose alone (less than 1.5 mU/l from 45 to 135 min after glucose ingestion). When hpGRF 1-44 was injected 60 min after oral glucose, the growth hormone response was attenuated (maximum, 6.7 +/- 1.4 mU/l at 15 min, P less than 0.05). Increments of blood glucose within the physiological range diminish the growth hormone response to hpGRF 1-44 in normal man.

摘要

在六名正常受试者中，研究了75克口服葡萄糖负荷对生长激素分泌的抑制作用与人胰腺生长激素释放因子1 - 44（hpGRF 1 - 44，静脉注射10微克）的刺激作用之间的相互作用。单独使用hpGRF 1 - 44可使生长激素浓度升高（注射后15分钟时，最大平均±标准误为16.5±1.7 mU/l），而单独口服葡萄糖可抑制生长激素水平（摄入葡萄糖后45至135分钟时低于1.5 mU/l）。当在口服葡萄糖60分钟后注射hpGRF 1 - 44时，生长激素反应减弱（15分钟时最大值为6.7±1.4 mU/l，P<0.05）。生理范围内的血糖升高会减弱正常人对hpGRF 1 - 44的生长激素反应。