与针对MCG本斯-琼斯蛋白的独特型抗体发生反应的五种人λ链蛋白的可变区序列。
Variable-region sequences of five human lambda-chain proteins reacting with an idiotypic antibody to the MCG Bence-Jones protein.
作者信息
Zhu D, Kim H S, Deutsch H F
出版信息
Mol Immunol. 1983 Oct;20(10):1107-16. doi: 10.1016/0161-5890(83)90120-7.
PMID:6425645
Abstract
An antibody to the V-region of BJ protein MCG has been used to detect other human lambda-chains with similar idiotypic specificities. Five such proteins have been found and sequenced. They show relatively strong sequence homologies to some segments of the MCG V-region. The results of this study indicate that L-chains which contain short segments of their V-regions that are identical can be readily detected by the use of appropriate antisera.
摘要
一种针对BJ蛋白MCG可变区的抗体已被用于检测其他具有相似独特型特异性的人λ链。现已发现并测序了5种这样的蛋白。它们与MCG可变区的某些片段显示出相对较强的序列同源性。这项研究的结果表明，通过使用合适的抗血清，可以很容易地检测到其可变区含有相同短片段的轻链。
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