Munthe E, Jellum E
Scand J Rheumatol Suppl. 1983;51:46-51. doi: 10.3109/03009748309095343.
It is postulated that the efficacy of sodium aurothiomalate and d-penicillamine could be partly dependent on the activity of sulphydryl groups. Free thiomalate, the thiol from sodium aurothiomalate was shown to be liberated in vivo and has been detected in the blood and urine of sodium aurothiomalate-treated patients. An increase in intracellular glutathione levels in response to treatment with sodium aurothiomalate and penicillamine was demonstrated and considered to be related to these drugs' properties as thiols. A pilot clinical trial using sodium thiomalate treatment demonstrated clinical improvement in four out of six patients after one course. Two patients relapsed but both improved after a second course and there were no serious adverse reactions. It is concluded that although larger controlled clinical trials are required, the role of gold in "chrysotherapy" must remain in question.
据推测，硫代苹果酸金钠和d-青霉胺的疗效可能部分取决于巯基的活性。硫代苹果酸金钠中的游离硫代苹果酸（一种硫醇）已被证明可在体内释放，并已在接受硫代苹果酸金钠治疗的患者的血液和尿液中检测到。已证实，用硫代苹果酸金钠和青霉胺治疗后，细胞内谷胱甘肽水平会升高，并被认为与这些药物作为硫醇的特性有关。一项使用硫代苹果酸钠治疗的临床试验初步结果显示，六名患者中有四名在一个疗程后临床症状有所改善。两名患者复发，但在第二个疗程后均有所改善，且未出现严重不良反应。结论是，尽管需要进行更大规模的对照临床试验，但金在“金疗法”中的作用仍有待质疑。
