Domingo J L, Llobet J M, Corbella J
Toxicol Eur Res. 1983 Nov;5(6):251-5.
The effect of EDTA on acute cobalt toxicity in rats was the subject of our investigation. There was complete effectiveness for two methods of treatment of the Co and EDTA, except when the CoCl2 was given orally and EDTA intraperitoneally. When the CoCl2-EDTA complex was given orally or intraperitoneally there were no deaths, not even at LD100 values of the CoCl2. No noteworthy changes were brought about in the hematological parameters and serum parameters of the animals receiving the CoCl2-EDTA complexes after a week's treatment. Significant differences appeared in the variation of some blood parameters measured 12 hours after the administration of the Co/CH3-COO)2-EDTA complex compared with the same parameters measured on giving only Co(CH3-COO)2.
乙二胺四乙酸（EDTA）对大鼠急性钴中毒的影响是我们研究的主题。除了氯化钴经口给药而EDTA经腹腔给药的情况外，两种钴和EDTA的治疗方法均完全有效。当口服或腹腔注射氯化钴-EDTA复合物时，即使给予氯化钴的半数致死量（LD100）也不会导致死亡。经过一周的治疗后，接受氯化钴-EDTA复合物的动物的血液学参数和血清参数没有出现值得注意的变化。与仅给予乙酸钴[Co(CH3-COO)2]相比，在给予乙酸钴-EDTA复合物12小时后测量的一些血液参数变化出现了显著差异。
