May P, Pilorz H, Duhme C, Pöpperl H, Braun J
Urologe A. 1984 Mar;23(2):87-90.
In 30 cases of recurring urinary calcium oxalate and calcium phosphate calculi, renal or absorptive hypercalciuria or hyperuricemia, long term controls of serum and urine electrolytes were made under hydrochlorothiazide and allopurinol therapy. By differentiating the type of hypercalciuria it could be determined, if thiazide-therapy is indicated in renal hypercalciuria only or in the absorptive cases as well. Statistic comparison of the patients with - and without increased urinary sodium excretion solved the question whether high sodium excretion diminishes or abolishes the hypocalciuric thiazide effect. The frequency of stones before and after treatment supports the efficacy of thiazide prophylaxis.
在30例复发性草酸钙和磷酸钙肾结石、肾性或吸收性高钙尿症或高尿酸血症患者中，在氢氯噻嗪和别嘌醇治疗下对血清和尿液电解质进行了长期监测。通过区分高钙尿症的类型，可以确定噻嗪类疗法仅适用于肾性高钙尿症还是也适用于吸收性高钙尿症病例。对尿钠排泄增加和未增加的患者进行统计学比较，解决了高钠排泄是否会降低或消除噻嗪类药物的降钙尿作用这一问题。治疗前后结石的发生率支持噻嗪类药物预防的有效性。
