Ala-Opas M, Elomaa I, Porkka L, Alfthan O
Second Department of Surgery, University of Helsinki, Finland.
Scand J Urol Nephrol. 1987;21(4):311-4. doi: 10.3109/00365598709180789.
Both urinary calcium excretion and renal stone episodes are increased during the summer in Finland. Since thiazide and unprocessed bran are known to decrease urinary calcium excretion, we treated 73 patients with recurrent urinary stone formation by giving them unprocessed bran and intermittent thiazide. Of the patients, 32 had absorptive hypercalciuria and 41 had normal urinary calcium values. All patients were on a low-calcium and low-oxalate diet and took 40 g bran daily. Fourteen of the hypercalciuric and 14 of the normocalciuric patients were randomly allocated to use hydrochlorothiazide 50 mg b.i.d. from May to September. Reduction of stone formation was seen in all groups. The combination of thiazide + bran was superior to the bran on its own in inhibition of stone formation. Only 3/11 (27%) stones passed through during the summer in the thiazide + bran group as compared with the 11/17 (65%) in the bran group.
在芬兰，夏季尿钙排泄量和肾结石发作次数都会增加。由于已知噻嗪类药物和未加工的麸皮可减少尿钙排泄，我们对73例复发性尿路结石形成患者给予未加工的麸皮和间歇性噻嗪类药物进行治疗。其中，32例患者有吸收性高钙尿症，41例患者尿钙值正常。所有患者均采用低钙和低草酸饮食，每天服用40克麸皮。14例高钙尿症患者和14例正常钙尿症患者被随机分配在5月至9月期间每天服用两次50毫克氢氯噻嗪。所有组的结石形成均有所减少。噻嗪类药物+麸皮组合在抑制结石形成方面优于单独使用麸皮。在夏季，噻嗪类药物+麸皮组中只有3/11（27%）的结石排出，而麸皮组为11/17（65%）。
