Donham K J, Zavala D C, Merchant J
Am J Ind Med. 1984;5(5):367-75. doi: 10.1002/ajim.4700050505.
A sample population of owner/operators of swine confinement production facilities (21 subjects in 21 different facilities) were tested by spirometry immediately before and after a 4-hr work period. These confinement workers had statistically significant decrements in flow rates ranging from 3.3% (mean FVC) to 11.9% (mean FEF25-75). The air within the work environment was sampled for particulates and gases during the exposure period. There was suggestive evidence for a dose-response association between environmental exposures to carbon dioxide (CO2) and hydrogen sulfide (H2S). There was also some evidence for an additive relationship between smoking and work environment exposure on decline in lung function. The results of this study indicate that those working in swine confinement buildings experience irritation to the respiratory tract which is manifest by decreased flow rates. These findings suggest this exposure represents an emerging occupational health hazard. Further studies are warranted to assess the potential for chronic or irreversible damage to the respiratory tract.
对一组猪舍养殖设施的业主/经营者样本（21个不同设施中的21名受试者）在4小时工作时段前后立即进行了肺活量测定。这些猪舍工人的流速出现了具有统计学意义的下降，降幅从3.3%（平均用力肺活量）到11.9%（平均用力呼气流量25%-75%）。在暴露期间对工作环境中的空气进行了颗粒物和气体采样。有迹象表明环境中二氧化碳（CO2）和硫化氢（H2S）暴露之间存在剂量反应关联。也有一些证据表明吸烟与工作环境暴露在肺功能下降方面存在相加关系。本研究结果表明，在猪舍工作的人员会出现呼吸道刺激，表现为流速降低。这些发现表明这种暴露是一种新出现的职业健康危害。有必要进行进一步研究以评估对呼吸道造成慢性或不可逆损害的可能性。
