Muasher S, Acosta A A, Garcia J E, Jones G S, Jones H W
Fertil Steril. 1984 Jun;41(6):838-43. doi: 10.1016/s0015-0282(16)47895-7.
One hundred seventy-five cycles in patients with irreparable tubal disease were stimulated by human menopausal gonadotropin/human chorionic gonadotropin for the purpose of in vitro fertilization. The pregnancy rate was found to be related to the height and pattern of serum estradiol (E2) response in the follicular phase. The mean serum E2 and progesterone (P) during the luteal phase showed no statistically significant difference between the pregnant and nonpregnant patients in the series except after luteal day 11. The mean serum E2 in most of the luteal phase days was highest in the high responders followed by the normal and the low responders. However, the mean P values were similar for the high and normal responders but higher than the low responders on cycle days 18, 20, and 22. The mean serum E2 and P in the luteal phase showed no statistically significant difference among the three most common patterns. This was also true for the pregnant and nonpregnant values in each category of height and pattern of response. We concluded that the success and failure of in vitro fertilization was probably less related to the peripheral E2 and P in the luteal phase than to the number and quality of eggs.
对175例输卵管疾病无法修复的患者进行了175个周期的体外受精促排卵治疗，使用人绝经期促性腺激素/人绒毛膜促性腺激素进行刺激。研究发现，妊娠率与卵泡期血清雌二醇（E2）反应的高度和模式有关。除黄体期第11天之后外，该系列中妊娠患者与未妊娠患者黄体期的血清E2和孕酮（P）均值无统计学显著差异。在黄体期的大多数日子里，高反应者的血清E2均值最高，其次是正常反应者和低反应者。然而，在周期第18、20和22天，高反应者和正常反应者的P均值相似，但高于低反应者。黄体期血清E2和P均值在三种最常见模式之间无统计学显著差异。在每种反应高度和模式类别中，妊娠和未妊娠的值也是如此。我们得出结论，体外受精的成功与失败可能与黄体期外周E2和P的关系较小，而与卵子的数量和质量关系较大。
