Alpers C E, Hopper J, Biava C G
Hum Pathol. 1984 May;15(5):444-8. doi: 10.1016/s0046-8177(84)80078-7.
A 40-year-old man with rapidly progressive renal failure was found to have a lobular glomerulonephritis by renal biopsy. Immunofluorescent microscopy showed prominent glomerular deposition of both kappa and lambda light chains but no significant heavy-chain component. Ultrastructurally, electron-dense deposits in the mesangium and capillary basement membranes had a fibrillar appearance indistinguishable from amyloid. This case illustrates a "light-chain glomerulopathy" distinct from previously reported glomerulopathies associated with the deposition of light chains of a single subclass.
一名40岁男性，患有快速进展性肾衰竭，经肾活检发现为小叶性肾小球肾炎。免疫荧光显微镜检查显示κ和λ轻链在肾小球有显著沉积，但重链成分不明显。超微结构上，系膜和毛细血管基底膜中的电子致密沉积物呈纤维状外观，与淀粉样蛋白难以区分。该病例说明了一种“轻链肾小球病”，与先前报道的与单一亚类轻链沉积相关的肾小球病不同。
