Fuchs P C, Gustafson M E, King J T, Goodall P T
Infect Control. 1984 May;5(5):226-30. doi: 10.1017/s0195941700060161.
One hundred fifty Hickman right atrial catheters were inserted into 143 patients and were followed prospectively until removal. Primary indications for their use were: cancer chemotherapy (45), parenteral nutrition (35), antibiotic therapy (63), and miscellaneous (7). The overall catheter-associated infection rate was 12.0%. Since the mean duration of catheterization was 125 days, the infection/duration rate was 1.0/1,000 days of use. The risk of infection differed significantly according to the primary indication for catheterization: parenteral nutrition greater than antibiotic therapy greater than cancer chemotherapy. The increased risk of catheter-associated infection attributable to duration of catheterization was additive, and the per day risk of such infections remained constant regardless of duration. Nearly two-thirds of patients were discharged home with catheters in place, without adversely affecting infection risk.
150根Hickman右心房导管被插入143例患者体内，并进行前瞻性随访直至拔除。使用这些导管的主要适应证为：癌症化疗（45例）、肠外营养（35例）、抗生素治疗（63例）及其他（7例）。导管相关感染的总体发生率为12.0%。由于平均置管时间为125天，感染/置管时间率为每使用1000天发生1.0次感染。根据置管的主要适应证不同，感染风险有显著差异：肠外营养大于抗生素治疗大于癌症化疗。因置管时间导致的导管相关感染风险增加具有累加性，且此类感染的每日风险与置管时间无关，保持恒定。近三分之二的患者带管出院回家，这并未对感染风险产生不利影响。
