Menitove S M, Rapoport D M, Epstein H, Sorkin B, Goldring R M
J Appl Physiol Respir Environ Exerc Physiol. 1984 Apr;56(4):1039-44. doi: 10.1152/jappl.1984.56.4.1039.
The relationship between the resting response to CO2 rebreathing and the ventilatory response to CO2 production during exercise was examined in 20 healthy untrained male subjects and in six patients with obesity hypoventilation syndrome. Patients were chosen because of a severely reduced response to CO2 rebreathing. There was no correlation between the CO2 rebreathing response and the exercise ventilatory response in the normal subjects, the patients, or in the group considered as a whole. This lack of correlation could not be accounted for by differences in ventilatory and occlusion pressure responses nor by reporting responses as a function of a change in hydrogen ion concentration. The independence of the CO2 rebreathing response and the exercise ventilatory response suggests the CO2 rebreathing response does not measure the relevant parameters of ventilatory control during exercise.
在20名健康的未经训练的男性受试者和6名肥胖低通气综合征患者中，研究了静息状态下对二氧化碳再呼吸的反应与运动期间对二氧化碳产生的通气反应之间的关系。选择这些患者是因为他们对二氧化碳再呼吸的反应严重降低。在正常受试者、患者或作为一个整体的组中，二氧化碳再呼吸反应与运动通气反应之间均无相关性。这种缺乏相关性不能通过通气和闭塞压力反应的差异来解释，也不能通过将反应报告为氢离子浓度变化的函数来解释。二氧化碳再呼吸反应和运动通气反应的独立性表明，二氧化碳再呼吸反应无法测量运动期间通气控制的相关参数。
