Pasternack M S, Bevan M J, Klein J R
J Immunol. 1984 Jul;133(1):277-80.
We have examined the potential of murine cytotoxic T lymphocytes (CTL) to synthesize both IFN-gamma and IFN-alpha, beta by using three cloned antigen-reactive CTL lines. These lines, which produce IFN-gamma in an antigen-specific manner or after stimulation with mitogen, were also found to produce IFN-alpha, beta upon nonspecific contact with Newcastle disease virus. The requirement for viral integrity in this process has been examined. Virus infectivity was not necessary to stimulate the release of IFN-alpha, beta from CTL, but acid-inactivation of virus abrogated its IFN-inducing property.
我们利用三个克隆的抗原反应性细胞毒性T淋巴细胞（CTL）系，研究了小鼠CTL合成γ干扰素和α、β干扰素的潜力。这些细胞系能以抗原特异性方式产生γ干扰素，或在有丝分裂原刺激后产生γ干扰素，我们还发现，它们在与新城疫病毒非特异性接触后会产生α、β干扰素。我们已经研究了该过程中对病毒完整性的要求。病毒感染性并非刺激CTL释放α、β干扰素所必需，但病毒经酸灭活后会丧失其诱导干扰素的特性。
