Suzuki F, Pollard R B
J Immunol. 1982 Nov;129(5):1806-10.
The effect of thermal injury on the response of interferon (IFN) production in vivo and in vitro after stimulation with eight representative inducers was investigated in a mouse model. The response of mice to immune IFN (IFN-gamma) inducers, staphylococcal enterotoxin A, concanavalin A, and a specific antigen for BCG-sensitized lymphocytes (purified protein derivative) was impaired after a 30% total body surface area third-degree burn. Suppression of IFN-gamma production was observed at day 2 and persisted until day 7 after burn. Decreased IFN-gamma production correlated closely with the percentage of total body surface area burned. When virus type IFN (IFN-alpha/beta) inducers, Newcastle disease virus, polyriboinosinic-polyribocytidylic acid, 10-carboxymethyl-9-acridanone, and E. coli endotoxin, were administered to mice, no change in IFN response was observed after thermal injury. Similar results were obtained when spleen cells obtained from thermally injured mice were stimulated with IFN-gamma inducers in vitro. These studies suggest that although the capacity for IFN-alpha/beta production remains intact in thermally injured mice, IFN-gamma production may be selectively decreased in burned animals and in their spleen cells.
在小鼠模型中研究了热损伤对八种代表性诱导剂刺激后体内和体外干扰素（IFN）产生反应的影响。在全身表面积30%的三度烧伤后，小鼠对免疫干扰素（IFN-γ）诱导剂、葡萄球菌肠毒素A、刀豆球蛋白A以及卡介苗致敏淋巴细胞的特异性抗原（纯化蛋白衍生物）的反应受损。在烧伤后第2天观察到IFN-γ产生受到抑制，并持续到烧伤后第7天。IFN-γ产生的减少与烧伤的全身表面积百分比密切相关。当向小鼠施用病毒型干扰素（IFN-α/β）诱导剂新城疫病毒、聚肌苷酸-聚胞苷酸、10-羧甲基-9-吖啶酮和大肠杆菌内毒素时，热损伤后未观察到IFN反应的变化。当用IFN-γ诱导剂在体外刺激从热损伤小鼠获得的脾细胞时，也得到了类似的结果。这些研究表明，虽然热损伤小鼠中IFN-α/β的产生能力保持完整，但烧伤动物及其脾细胞中IFN-γ的产生可能会选择性降低。
