用4-硝基喹啉-1-氧化物在小鼠中实验性诱导口腔鳞状细胞癌。

Experimental induction of oral squamous cell carcinomas in mice with 4-nitroquinolone-1-oxide.

作者信息

Steidler N E, Reade P C

出版信息

Oral Surg Oral Med Oral Pathol. 1984 May;57(5):524-31. doi: 10.1016/0030-4220(84)90312-8.

Abstract

The oral mucosa of mice is resistant to the action of a variety of carcinogens. In this study, the water-soluble carcinogen 4-nitroquinoline-1-oxide (4NQO) was applied repeatedly to the palates of male CBA mice for 2, 4, 6, 8, 12, or 16 weeks, and the animals were observed for the remainder of the 50-week experimental period. Oral epithelial atypia and squamous cell carcinoma were observed with increasing prevalence as the period of carcinogen exposure was increased. Carcinomas developed by 50 weeks in all animals that received 4NQO for 16 weeks.

摘要

小鼠的口腔黏膜对多种致癌物具有抗性。在本研究中，将水溶性致癌物4-硝基喹啉-1-氧化物（4NQO）反复应用于雄性CBA小鼠的腭部，持续2、4、6、8、12或16周，并在50周的实验期剩余时间内观察这些动物。随着致癌物暴露时间的增加，口腔上皮异型增生和鳞状细胞癌的发生率逐渐升高。在接受4NQO处理16周的所有动物中，到50周时均发生了癌症。