Werlen C, Py P, Haab P
Respir Physiol. 1984 Feb;55(2):205-21. doi: 10.1016/0034-5687(84)90023-9.
In order to compare the efficiency of sheep lung with that of dog, gaseous exchange in hypoxia (FIO2 0.12-0.13) with and without CO in the inspired air ( FICO 0.001) was measured in 12 sheep (mean body weight = 30.4 kg) under pentothal anesthesia and artificial ventilation. Alveolar-arterial pressure difference of O2, % venous admixture and amount of VA/Q inhomogeneity were found to be substantially larger than in dog. Steady-state pulmonary diffusing capacity estimates, computed by three different procedures were, both for O2 and for CO, about 40% smaller than in dog. The DLO2/DLCO ratios were not significantly different from those determined on dog data: thus, the presumed beneficial effect of sheep small erythrocytes on O2 transfer could not be demonstrated. Because its DLO2/MO2 ratio is lower than that of dog, sheep appears to be more adequate than dog as a model for human alveolar-arterial gas exchange.
为了比较绵羊肺与狗肺的效率，在硫喷妥钠麻醉和人工通气下，对12只绵羊（平均体重=30.4千克）测量了在吸入空气中有和没有一氧化碳（FICO 0.001）的情况下，低氧（FIO2 0.12 - 0.13）时的气体交换。发现绵羊的氧肺泡 - 动脉压差、静脉混合百分比和VA/Q不均匀程度均显著大于狗。通过三种不同方法计算的稳态肺扩散容量估计值，无论是氧气还是一氧化碳，都比狗的约小40%。DLO2/DLCO比值与根据狗的数据确定的比值没有显著差异：因此，无法证明绵羊小红细胞对氧气转运的假定有益作用。由于绵羊的DLO2/MO2比值低于狗，作为人类肺泡 - 动脉气体交换的模型，绵羊似乎比狗更合适。
