Zak I, Steibert E, Leszczyńska E
Med Pr. 1978;29(1):1-7.
In experimental cadmium intoxication 100 rats were intraperitoneally injected with single doses of 0; 5 1,0, 2,0 5,0 mg Cd++/kg body weight as well as with 14 doses of 0,25 mg Cd++/kg. In the serum of animals the level of total protein and of glycoprotein carbohydrate components was determined. After doses in the range of cadmium concentration from 0,5 to 2,0 mg Cd++/kg body weight, a statistically and significant increase of the serum level of the protein-bound hexose hexoamine and sialic acids was stated. On the other hand the dose of 5,0 mg Cd++/kg caused only the increase of hexose in comparison with values of these constituents recorded in the control group. In animals receiving multiple doses of cadmium and also in those after a single administration of 1,0 mg Cd++/kg, a significant increase of the total protein level was started. The last group revealed the highest concentrations of protein and glycoprotein carbohydrate constituents on the third day after injection of cadmium while after 14 days, amouunts of these compounds approximated the levels estimated in the control group. A univocal evaluation of the obtained results is difficult, however in the mechanism of the quantitative alterations within the glycoprotein components of rats serum, the possibility of cadmium--induced biosynthesis of these compounds should be taken into consideration.
在实验性镉中毒研究中，给100只大鼠腹腔注射单剂量的0、5、1.0、2.0、5.0毫克Cd++/千克体重，以及14剂量的0.25毫克Cd++/千克体重。测定动物血清中总蛋白和糖蛋白碳水化合物成分的水平。在镉浓度范围为0.5至2.0毫克Cd++/千克体重的剂量后，血清中与蛋白质结合的己糖、己糖胺和唾液酸水平出现统计学上的显著升高。另一方面，5.0毫克Cd++/千克体重的剂量仅导致己糖相对于对照组记录的这些成分的值增加。在接受多剂量镉的动物以及单次给予1.0毫克Cd++/千克体重的动物中，总蛋白水平开始显著升高。最后一组在注射镉后第三天显示出蛋白质和糖蛋白碳水化合物成分的最高浓度，而在14天后，这些化合物的量接近对照组估计的水平。然而，对所得结果进行明确评估很困难，不过在大鼠血清糖蛋白成分定量改变的机制中，应考虑镉诱导这些化合物生物合成的可能性。
