[实验性甲状腺功能减退对大鼠血清糖蛋白组分及其含糖成分的影响]

[Effect of experimental hypothyreosis on glycoprotein fractions and their carbohydrate-containing components in rat blood serum].

作者信息

Kuz'mak N I

出版信息

Vopr Med Khim. 1975 Jul-Aug;21(4):346-51.

Abstract

In blood serum of rats with experimental hypothyreosis content of albumins, alpha2- gamma-globulins and ceruloplasmin was decreased but content of alpha1-, beta-globulins, seromucoids, sialic acids, hexoses bound with proteins, hexoseamines, haptoglobulins, transferrins and fucose was increased. The most distinct alterations in metabolism of glycoproteins were observed in rats with hypothyreosis, caused by thyroidectomy or by administration of large doses of thyreostatics. A correlation was observed between the alteration in ratios of the protein fractions and content of different carbohydrate containing components of glycoproteins. In the animals examined normalization in content of different carbohydrate containing components of blood occurred with 24-36 days after termination of the thyreostatic administration. In rats with thyroidectomy the process was prolonged up to 2 months and more.

摘要

在实验性甲状腺功能减退大鼠的血清中，白蛋白、α2-γ球蛋白和铜蓝蛋白的含量降低，但α1-、β球蛋白、血清类粘蛋白、唾液酸、与蛋白质结合的己糖、己糖胺、触珠蛋白、转铁蛋白和岩藻糖的含量增加。在因甲状腺切除或给予大剂量甲状腺抑制剂而导致甲状腺功能减退的大鼠中，观察到糖蛋白代谢最明显的改变。蛋白质组分比例的变化与糖蛋白中不同含碳水化合物成分的含量之间存在相关性。在接受甲状腺抑制剂治疗终止后24 - 36天，所检查动物血液中不同含碳水化合物成分的含量恢复正常。对于甲状腺切除的大鼠，这一过程延长至2个月及更长时间。