[Effect of experimental hypothyreosis on glycoprotein fractions and their carbohydrate-containing components in rat blood serum].

In blood serum of rats with experimental hypothyreosis content of albumins, alpha2- gamma-globulins and ceruloplasmin was decreased but content of alpha1-, beta-globulins, seromucoids, sialic acids, hexoses bound with proteins, hexoseamines, haptoglobulins, transferrins and fucose was increased. The most distinct alterations in metabolism of glycoproteins were observed in rats with hypothyreosis, caused by thyroidectomy or by administration of large doses of thyreostatics. A correlation was observed between the alteration in ratios of the protein fractions and content of different carbohydrate containing components of glycoproteins. In the animals examined normalization in content of different carbohydrate containing components of blood occurred with 24-36 days after termination of the thyreostatic administration. In rats with thyroidectomy the process was prolonged up to 2 months and more.