Dean J M, Hoehner P J, Rogers M C, Traystman R J
Stroke. 1984 May-Jun;15(3):531-5. doi: 10.1161/01.str.15.3.531.
Lidoflazine, a calcium channel blocker, was administered to dogs following twelve minutes of cerebral ischemia, induced by aortic cross-clamping. The effects of lidoflazine (1 mg/kg i.v.) on cerebral blood flow following ischemia was studied in 15 anesthetized, mechanically ventilated dogs. Cerebral blood flow was measured with the radiolabelled microsphere technique before and 10, 30, 60, 90 and 150 minutes following ischemia. Cerebral blood flow increased in all brain regions following ischemia, but by 60 minutes had decreased to control values. Lidoflazine had no effect on this reperfusion phenomenon, or on the distribution of blood flow within the brain. Regional cerebral blood flow was also not altered by lidoflazine therapy. Our data demonstrate that this dose of lidoflazine has no effect on regional or total cerebral blood flow following 12 minutes of cerebral ischemia in dogs. These data do not support perfusion preservation as a mechanism of amelioration of neurologic injury after ischemia by this calcium channel blocker.
利多氟嗪是一种钙通道阻滞剂，在通过主动脉交叉夹闭诱导犬脑缺血12分钟后给予。在15只麻醉、机械通气的犬中研究了利多氟嗪（1毫克/千克静脉注射）对缺血后脑血流量的影响。在缺血前以及缺血后10、30、60、90和150分钟，用放射性标记微球技术测量脑血流量。缺血后所有脑区的脑血流量均增加，但到60分钟时已降至对照值。利多氟嗪对这种再灌注现象或脑内血流分布没有影响。利多氟嗪治疗也未改变局部脑血流量。我们的数据表明，该剂量的利多氟嗪对犬脑缺血12分钟后的局部或全脑血流量没有影响。这些数据不支持灌注保存是这种钙通道阻滞剂减轻缺血后神经损伤的机制。
