Phillis J W, DeLong R E, Towner J K
Eur J Pharmacol. 1985 Jun 19;112(3):323-9. doi: 10.1016/0014-2999(85)90777-0.
Cerebral blood flow in the rat was monitored by a venous outflow technique with an extracorporeal circulation, which allows for the continuous recording of flow over periods of several hours. The bi-fluorophenyl-piperazine derivatives, lidoflazine and flunarizine, enhanced the reactive hyperemia elicited by a brief (30 s) anoxic challenge. They did not alter resting cerebral blood flow rates. Verapamil, a potent calcium slow channel blocker, decreased resting flow rates but did not alter the duration of the reactive hyperemia. As lidoflazine and flunarizine are potent inhibitors of adenosine uptake, whereas verapamil is not, the results are consistent with the hypothesis that adenosine plays a significant role in cerebral vascular autoregulation.
采用体外循环静脉流出技术监测大鼠脑血流量，该技术可连续记录数小时的血流量。双氟苯基哌嗪衍生物利多氟嗪和氟桂利嗪可增强短暂（30秒）缺氧刺激引起的反应性充血。它们不会改变静息脑血流速率。强效钙慢通道阻滞剂维拉帕米可降低静息血流速率，但不会改变反应性充血的持续时间。由于利多氟嗪和氟桂利嗪是腺苷摄取的强效抑制剂，而维拉帕米不是，因此这些结果与腺苷在脑血管自动调节中起重要作用的假设一致。
