[血液病患儿免疫干扰素的形成]
[Formation of immune interferon in children with hemoblastoses].
作者信息
Pavlushina S V, Orlova T G, Gavrilova I E
出版信息
Vopr Virusol. 1984 Mar-Apr;29(2):183-8.
Production of immune interferon by bone marrow mononuclears stimulated by phytohemagglutinin was experimentally demonstrated in vitro. The most effective dose of mitogen in this cell system was found to be 10 micrograms/ml, and the maximum gamma-interferon response was observed at 6-7 days of cultivation. At the same time, cultures of the peripheral blood mononuclears showed two peaks of antiviral activity: at 3 and 7 days. Comparison of interferon production in parallel cultures of blood and bone marrow mononuclears showed the potentials of mononuclears from both systems to be similar despite obvious heterogeneity of the cell composition of lymphoid cell populations.
体外实验证明了植物血凝素刺激的骨髓单核细胞可产生免疫干扰素。在该细胞系统中，发现丝裂原的最有效剂量为10微克/毫升，培养6-7天时观察到γ干扰素的最大反应。同时，外周血单核细胞培养物显示出两个抗病毒活性峰值：分别在第3天和第7天。血液和骨髓单核细胞平行培养物中干扰素产生的比较表明，尽管淋巴细胞群体的细胞组成明显异质性，但两个系统的单核细胞产生干扰素的潜力相似。
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