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[人类外周神经的抗原]

[Antigens of human peripheral nerves].

作者信息

Umerov Zh G

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1984;84(4):494-8.

PMID:6428093
Abstract

The antigens of the peripheral nerves in man were studied by immuno and physicochemical methods. The composition of the peripheral nerves was shown to include antigens of wide specificity which can be found in many organs and tissues of the body. Moreover, antigens of narrow specificity (of the peripheral and the central nervous system) and a specific antigen of the peripheral nerves were identified. Separate peripheral nerves do not differ from each other according to the specific antigens. The specific antigen is thermostable, resistant to the acids and urea and does not fall into sedimentation at 100% saturation with ammonium sulphite. By electrophoretic mobility (similar to serum gamma-globulins) it belongs to cathode proteins. In accordance to its properties, it is designated as a gamma-neurospecific antigen (gamma-NSA).

摘要

采用免疫和物理化学方法对人体周围神经的抗原进行了研究。结果表明,周围神经的组成包括具有广泛特异性的抗原,这些抗原可在身体的许多器官和组织中找到。此外,还鉴定出了具有狭窄特异性的抗原(周围神经系统和中枢神经系统的抗原)以及周围神经的一种特异性抗原。不同的周围神经在特异性抗原方面并无差异。该特异性抗原具有热稳定性,耐酸和尿素,在硫酸铵100%饱和时不发生沉淀。根据其电泳迁移率(类似于血清γ球蛋白),它属于阴极蛋白。根据其性质,它被命名为γ-神经特异性抗原(γ-NSA)。

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