[Comparative immunochemical and physicochemical study of the neurospecific antigen 10-40-4 from human and rat brains].

Immunological non-identity of neurospecific protein 10-40-4 from various mammalian species has been demonstrated. Significant immunochemical differences were found between the protein 10-40-4 from the brain of rat, guinea pig and man. With respect to their physicochemical properties, no significant differences were found between individual neurospecific proteins 10-40-4 from the brain of man and rat. Therefore, immunological differences in the structure of a neurospecific determinant together with identical physicochemical properties of the proteins investigated imply that the latter are presented by species variations of the same protein.