Baxter R C, Turtle J R
Metabolism. 1978 May;27(5):503-6. doi: 10.1016/0026-0495(78)90014-8.
Insulin (1 mU/ml) stimulated the incorporation of 14C-leucine into trichloroacetic acid-precipitable material by isolated hepatocytes from normal and hypophysectomized adult rats and 12-day-old rabbits. Somatomedin (200 ng/ml) purified from human plasma had an insulinlike effect in hepatocytes from hypophysectomized rats and baby rabbits but not from normal rats. This study suggests that, as well as being a site of somatomedin synthesis, the liver may be a target organ for this hormone.
胰岛素(1毫单位/毫升)可刺激正常成年大鼠、垂体切除成年大鼠以及12日龄家兔的离体肝细胞将14C-亮氨酸掺入三氯乙酸沉淀物质中。从人血浆中纯化得到的生长调节素(200纳克/毫升)对垂体切除大鼠和幼兔的肝细胞具有胰岛素样作用,但对正常大鼠的肝细胞则无此作用。本研究表明,肝脏不仅是生长调节素的合成部位,可能还是该激素的靶器官。