• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

生长调节素对离体肝细胞蛋白质合成的刺激作用。

Stimulation of protein synthesis in isolated hepatocytes by somatomedin.

作者信息

Baxter R C, Turtle J R

出版信息

Metabolism. 1978 May;27(5):503-6. doi: 10.1016/0026-0495(78)90014-8.

DOI:10.1016/0026-0495(78)90014-8
PMID:642821
Abstract

Insulin (1 mU/ml) stimulated the incorporation of 14C-leucine into trichloroacetic acid-precipitable material by isolated hepatocytes from normal and hypophysectomized adult rats and 12-day-old rabbits. Somatomedin (200 ng/ml) purified from human plasma had an insulinlike effect in hepatocytes from hypophysectomized rats and baby rabbits but not from normal rats. This study suggests that, as well as being a site of somatomedin synthesis, the liver may be a target organ for this hormone.

摘要

胰岛素(1毫单位/毫升)可刺激正常成年大鼠、垂体切除成年大鼠以及12日龄家兔的离体肝细胞将14C-亮氨酸掺入三氯乙酸沉淀物质中。从人血浆中纯化得到的生长调节素(200纳克/毫升)对垂体切除大鼠和幼兔的肝细胞具有胰岛素样作用,但对正常大鼠的肝细胞则无此作用。本研究表明,肝脏不仅是生长调节素的合成部位,可能还是该激素的靶器官。

相似文献

1
Stimulation of protein synthesis in isolated hepatocytes by somatomedin.生长调节素对离体肝细胞蛋白质合成的刺激作用。
Metabolism. 1978 May;27(5):503-6. doi: 10.1016/0026-0495(78)90014-8.
2
Effect of GH and insulin on the generation of somatomedin by perfused rat liver.生长激素和胰岛素对灌流大鼠肝脏生成生长调节素的影响。
Endocrinol Jpn. 1982 Apr;29(2):141-7. doi: 10.1507/endocrj1954.29.141.
3
Rat hepatocyte insulin-like growth factor I and binding protein: effect of growth hormone in vitro and in vivo.大鼠肝细胞胰岛素样生长因子I及其结合蛋白:生长激素在体内外的作用
Endocrinology. 1985 Mar;116(3):1102-7. doi: 10.1210/endo-116-3-1102.
4
The effects of insulin and growth hormone on the release of somatomedin by the isolated rat liver.胰岛素和生长激素对离体大鼠肝脏生长调节素释放的影响。
Endocrinology. 1976 May;98(5):1214-9. doi: 10.1210/endo-98-5-1214.
5
Insulin stimulates synthesis of soluble proteins in isolated rat hepatocytes.胰岛素刺激分离的大鼠肝细胞中可溶性蛋白质的合成。
Biochem J. 1980 Sep 15;190(3):615-9. doi: 10.1042/bj1900615.
6
Further characterization of growth hormone-dependent somatomedin-binding proteins in rat serum and demonstration of somatomedin-binding proteins produced by rat liver cells in culture.大鼠血清中生长激素依赖性生长调节素结合蛋白的进一步特性鉴定以及培养的大鼠肝细胞产生的生长调节素结合蛋白的证明。
Endocrinology. 1979 Feb;104(2):536-46. doi: 10.1210/endo-104-2-536.
7
Action of rat prolactin on plasma somatomedin levels in the rat and on somatomedin release from perfused rat liver.
J Endocrinol. 1977 Oct;75(1):137-43. doi: 10.1677/joe.0.0750137.
8
Effect of somatomedin A and insulin on cyclic AMP generation in isolated rat hepatocytes.
Horm Metab Res. 1980;12(6):251-6. doi: 10.1055/s-2007-996260.
9
Somatomedin-C stimulates glycogen synthesis in fetal rat hepatocytes.生长调节素-C刺激胎鼠肝细胞中的糖原合成。
Endocrinology. 1985 Jun;116(6):2578-82. doi: 10.1210/endo-116-6-2578.
10
Insulin stimulation of somatomedin A production in monolayer cultures of rat hepatocytes.
Acta Endocrinol (Copenh). 1983 Jul;103(3):385-90. doi: 10.1530/acta.0.1030385.

引用本文的文献

1
Alterations in circulating thyroid hormones and thyroxine-binding globulin levels during diabetic ketoacidosis.糖尿病酮症酸中毒期间循环甲状腺激素和甲状腺素结合球蛋白水平的变化。
J Endocrinol Invest. 1980 Jan-Mar;3(1):67-9. doi: 10.1007/BF03348220.
2
Insulin-like growth factor I binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal rat liver.胰岛素样生长因子I在人肝脏、人肝癌以及正常、再生和胎鼠肝脏的肝细胞中的结合情况。
J Clin Invest. 1988 Apr;81(4):976-81. doi: 10.1172/JCI113451.