Yeh J K, Aloia J F
Metabolism. 1978 May;27(5):507-9. doi: 10.1016/0026-0495(78)90015-x.
Serum somatomedin activity of rats was measured under several dietary conditions by 35S incorporation into chick embryo pelvic rudiment. The mean (+/- SD) serum somatomedin activity (U/ml) was reduced following 3 days of fasting (0.41 +/- 0.12) and increased to prefasting levels in animals fed a balanced diet (0.95 +/- 0.11) for 2 days. The increase in mean somatomedin activity following 2 days of refeeding a high-protein diet (0.79 +/- 0.09) was greater than that observed with a high-carbohydrate (0.56 +/- 0.10) or a high-fat (0.60 +/- 0.10) diet, but the level was not completely restored to normal. The data confirm the previous finding that fasting reduces serum somatomedin activity and suggest that the protein content of the diet plays a major role in the restoration of serum somatomedin activity following refeeding.
通过将³⁵S掺入鸡胚骨盆原基，在几种饮食条件下测量大鼠的血清生长调节素活性。禁食3天后，血清生长调节素活性平均值（±标准差）（U/ml）降低（0.41±0.12），而在喂食均衡饮食2天的动物中增加到禁食前水平（0.95±0.11）。重新喂食高蛋白饮食2天后，生长调节素活性平均值增加（0.79±0.09），高于高碳水化合物饮食（0.56±0.10）或高脂肪饮食（0.60±0.10），但该水平未完全恢复正常。这些数据证实了先前的发现，即禁食会降低血清生长调节素活性，并表明饮食中的蛋白质含量在重新喂食后血清生长调节素活性的恢复中起主要作用。
