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Synergistic antibacterial activity between L-norvalyl-L-1-aminoethylphosphonic acid and nocardicin A.L-正缬氨酰-L-1-氨基乙基膦酸与诺卡菌素A之间的协同抗菌活性。
Antimicrob Agents Chemother. 1984 May;25(5):607-11. doi: 10.1128/AAC.25.5.607.
2
Nocardicin A, a new monocyclic beta-lactam antibiotic III. In vitro evaluation.
J Antibiot (Tokyo). 1977 Nov;30(11):917-25. doi: 10.7164/antibiotics.30.917.
3
Aminoglycosides plus beta-lactams against gram-negative organisms. Evaluation of in vitro synergy and chemical interactions.氨基糖苷类药物与β-内酰胺类药物联合用于抗革兰氏阴性菌。体外协同作用及化学相互作用的评估。
Am J Med. 1986 Jun 30;80(6B):126-37. doi: 10.1016/0002-9343(86)90490-0.
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Chlorocardicin, a monocyclic beta-lactam from a Streptomyces sp. I. Discovery, production and biological activities.
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Potentiation of the in vitro activity of some antimicrobial agents against selected gram-negative bacteria by EDTA-tromethamine.乙二胺四乙酸-三羟甲基氨基甲烷增强某些抗菌剂对特定革兰氏阴性菌的体外活性
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Nocardicin A, a new monocyclic beta-lactam antibiotic IV. Factors influencing the in vitro activity of Nocardicin A.
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Nocardicin A, a new monocyclic beta-lactam antibiotic V. In vivo evaluation.诺卡菌素A，一种新型单环β-内酰胺抗生素V。体内评估。
J Antibiot (Tokyo). 1977 Nov;30(11):932-7. doi: 10.7164/antibiotics.30.932.
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Ceftolozane/tazobactam activity tested against aerobic Gram-negative organisms isolated from intra-abdominal and urinary tract infections in European and United States hospitals (2012).头孢洛扎/他唑巴坦对欧洲和美国医院腹腔内和尿路感染分离的需氧革兰氏阴性菌的活性检测（2012 年）。
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Use of the dehydrophos biosynthetic enzymes to prepare antimicrobial analogs of alaphosphin.利用去氢膦酰生物合成酶制备阿伐膦的抗菌类似物。
Org Biomol Chem. 2019 Jan 23;17(4):822-829. doi: 10.1039/c8ob02860e.

本文引用的文献

1
Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of biochemically related antimetabolites.核酸衍生物拮抗剂。VIII. 生物化学相关抗代谢物组合中的协同作用。
J Biol Chem. 1954 Jun;208(2):477-88.
2
Antibacterial properties of alafosfalin combined with cephalexin.阿拉磷与头孢氨苄联合使用的抗菌特性
Antimicrob Agents Chemother. 1981 Oct;20(4):470-6. doi: 10.1128/AAC.20.4.470.
3
Phosphonopeptide antibacterial agents related to alafosfalin: design, synthesis, and structure-activity relationships.与阿拉磷相关的膦肽抗菌剂：设计、合成及构效关系
Antimicrob Agents Chemother. 1980 Dec;18(6):897-905. doi: 10.1128/AAC.18.6.897.
4
The fractional inhibitory concentration (FIC) index as a measure of synergy.作为协同作用衡量指标的分数抑制浓度（FIC）指数。
J Antimicrob Chemother. 1983 May;11(5):427-33. doi: 10.1093/jac/11.5.427.
5
Therapeutic significance of nocardicin A stimulation of phagocyte function in experimental Pseudomonas aeruginosa infection.诺卡菌素A对实验性铜绿假单胞菌感染中吞噬细胞功能的刺激作用的治疗意义。
Br J Exp Pathol. 1983 Apr;64(2):231-7.
6
Penicillin-binding proteins of Pseudomonas aeruginosa. Comparison of two strains differing in their resistance to beta-lactam antibiotics.铜绿假单胞菌的青霉素结合蛋白。对β-内酰胺抗生素耐药性不同的两株菌株的比较。
J Antimicrob Chemother. 1981 Feb;7(2):127-36. doi: 10.1093/jac/7.2.127.
7
Penetration of beta-lactam antibiotics into their target enzymes in Pseudomonas aeruginosa: comparison of a highly sensitive mutant with its parent strain.β-内酰胺类抗生素对铜绿假单胞菌靶酶的渗透作用：高敏突变株与其亲本菌株的比较
Antimicrob Agents Chemother. 1980 Jul;18(1):94-100. doi: 10.1128/AAC.18.1.94.
8
Antibacterial activity and mechanism of action of phosphonopeptides based on aminomethylphosphonic acid.基于氨基甲基膦酸的膦肽的抗菌活性及作用机制
Antimicrob Agents Chemother. 1982 Oct;22(4):571-8. doi: 10.1128/AAC.22.4.571.
9
Interaction of nocardicin A with the penicillin-binding proteins of Escherichia coli in intact cells and in purified cell envelopes.诺卡菌素A与完整细胞及纯化细胞膜中大肠杆菌青霉素结合蛋白的相互作用。
Eur J Biochem. 1982 Aug;126(1):155-9. doi: 10.1111/j.1432-1033.1982.tb06760.x.
10
Induction of cell lysis in Escherichia coli: cooperative effect of nocardicin A and mecillinam.大肠杆菌中细胞裂解的诱导：诺卡菌素A和美西林的协同作用。
Antimicrob Agents Chemother. 1982 Feb;21(2):195-200. doi: 10.1128/AAC.21.2.195.

L-正缬氨酰-L-1-氨基乙基膦酸与诺卡菌素A之间的协同抗菌活性。

Synergistic antibacterial activity between L-norvalyl-L-1-aminoethylphosphonic acid and nocardicin A.

作者信息

Angehrn P, Hall M J, Lloyd W J, Westmacott D

出版信息

Antimicrob Agents Chemother. 1984 May;25(5):607-11. doi: 10.1128/AAC.25.5.607.

DOI:10.1128/AAC.25.5.607
PMID:6428312
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC185597/
Abstract

The phosphonopeptide L- norvalyl -L-1- aminoethylphosphonic acid [ Nva -Ala(P)] has been studied in combination with 12 beta-lactam antibiotics for activity against Pseudomonas aeruginosa. Nocardicin A was found to give the most potent synergistic combination with Nva -Ala(P). This interaction was widely observed in clinical isolates of P. aeruginosa in vitro and in a mouse septicemia model. Synergy was also observed in vitro and in vivo in several other species, including Proteus mirabilis, indole-positive Proteus spp., and Serratia marcescens. The interaction between Nva -Ala(P) and nocardicin A involved a strongly bacteriolytic mechanism. In addition, the individual components were complementary to one another in their action against organisms not showing synergy. These properties resulted in a broad spectrum of activity of the combination Nva -Ala(P) plus nocardicin A when used to treat experimental gram-negative bacterial infections.

摘要

已对膦肽L-正缬氨酰-L-1-氨基乙基膦酸[Nva-Ala(P)]与12种β-内酰胺类抗生素联合用于抗铜绿假单胞菌的活性进行了研究。发现诺卡菌素A与Nva-Ala(P)联合使用时具有最强的协同作用。这种相互作用在体外铜绿假单胞菌临床分离株和小鼠败血症模型中广泛观察到。在其他几种细菌中，包括奇异变形杆菌、吲哚阳性变形杆菌属和粘质沙雷氏菌，在体外和体内也观察到了协同作用。Nva-Ala(P)与诺卡菌素A之间的相互作用涉及一种强烈的溶菌机制。此外，各个组分在对抗未表现出协同作用的生物体时相互补充。当用于治疗实验性革兰氏阴性细菌感染时，这些特性导致Nva-Ala(P)加诺卡菌素A组合具有广泛的活性谱。