大肠杆菌中细胞裂解的诱导：诺卡菌素A和美西林的协同作用。
Induction of cell lysis in Escherichia coli: cooperative effect of nocardicin A and mecillinam.
作者信息
Berenguer J, de Pedro M A, Vázquez D
出版信息
Antimicrob Agents Chemother. 1982 Feb;21(2):195-200. doi: 10.1128/AAC.21.2.195.
Abstract
Nocardicin A and mecillinam are two beta-lactam antibiotics with poor bacteriolytic activity against Escherichia coli. However, the combined use of these drugs resulted in the induction of a fast lytic response in E. coli cells. For this cooperative effect to take place, the formation of a complex between penicillin-binding protein 2 and mecillinam is apparently necessary. This suggests that penicillin-binding protein 2 might be actively involved in the response of E. coli to bacteriolytic beta-lactam antibiotics.
摘要
诺卡菌素A和美西林是两种对大肠杆菌溶菌活性较差的β-内酰胺类抗生素。然而，这些药物的联合使用导致大肠杆菌细胞诱导出快速的溶菌反应。为了产生这种协同效应，青霉素结合蛋白2和美西林之间形成复合物显然是必要的。这表明青霉素结合蛋白2可能积极参与大肠杆菌对溶菌性β-内酰胺类抗生素的反应。
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Synergy of mecillinam, a beta-amidinopenicillanic acid derivative, combined with beta-lactam antibiotics.β-脒基青霉素酸衍生物美西林与β-内酰胺类抗生素的协同作用。
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Nocardicin A, a new monocyclic beta-lactam antibiotic. I. Discovery, isolation and characterization.诺卡菌素A，一种新型单环β-内酰胺抗生素。I. 发现、分离与特性鉴定。
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