Merli G J, McElwain G E, Adler A G, Martin J H, Roberts J D, Schnall B, Ditunno J F
Arch Intern Med. 1984 Jun;144(6):1286-8.
Hypercalcemia developed in a 30-year-old C5 quadriplegic six months after he received a gunshot wound in the cervical spine. Short-term treatment consisted of fluids and diuretics, but conventional drug therapy for long-term maintenance of normocalcemia was not effective. A regimen of etidronate disodium was then instituted, which resulted in normocalcemia. When use of this drug was discontinued at intervals during the therapy, the hypercalcemia recurred. The patient's condition was maintained on the etidronate regimen until full mobilization occurred, at which time the drug therapy was discontinued and normocalcemia persisted. This case represents, to our knowledge, the first reported success with the use of etidronate in the treatment of hypercalcemia in the immobilized patient with acute spinal injury.
一名30岁的C5级四肢瘫痪患者在颈椎受枪伤6个月后出现高钙血症。短期治疗包括补液和使用利尿剂，但用于长期维持血钙正常的传统药物治疗无效。随后采用了依替膦酸二钠治疗方案，结果血钙恢复正常。在治疗期间间歇性停用该药物时，高钙血症复发。患者的病情在依替膦酸治疗方案下得到维持，直到能够完全活动，此时停止药物治疗，血钙正常得以持续。据我们所知，该病例是首次报道使用依替膦酸成功治疗急性脊柱损伤固定患者的高钙血症。
