Petit A, Morelon P, Massin F, Diébold H, Brenot R, Louis P
Arch Mal Coeur Vaiss. 1984 May;77(5):586-9.
A case of severe systemic hypertension due to catecholamines discharge after ligation of a large patent ductus arteriosus in an 8 months old child is reported. The blood pressure was corrected by the association of alpha- and betablocker drugs which were withdrawn on the 15th post-operative day without recurrence. Transient increases in blood pressure are quite common after closure of a patent ductus arteriosus with a large shunt. Persistent hypertension greater than 160/110 mmHg is rare. It always regresses but may sometimes cause complications. Hyperactivity of the sympathetic nervous system has already been suggested as a possible cause. Massive discharge of catecholamines and the spectacular effect of the association of alpha- and betablocker therapy, reported here apparently for the first time, provide additional evidence in favour of this hypothesis.
本文报道了一例8个月大儿童在结扎大型动脉导管未闭后因儿茶酚胺释放导致严重全身性高血压的病例。联合使用α和β受体阻滞剂药物后血压得到纠正，术后第15天停用药物后未再复发。在大型分流的动脉导管未闭闭合后，血压短暂升高相当常见。持续性高血压大于160/110 mmHg很少见。它总是会消退，但有时可能会引起并发症。交感神经系统功能亢进已被认为是可能的原因。儿茶酚胺的大量释放以及本文首次报道的α和β受体阻滞剂联合治疗的显著效果，为这一假说提供了额外证据。
