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Inactivation of glucosamine-6-phosphate synthetase from Salmonella typhimurium LT 2 SL 1027 by N beta-fumarylcarboxyamido-L-2,3-diamino-propionic acid.

作者信息

Chmara H, Andruszkiewicz R, Borowski E

出版信息

Biochem Biophys Res Commun. 1984 May 16;120(3):865-72. doi: 10.1016/s0006-291x(84)80187-4.

DOI:10.1016/s0006-291x(84)80187-4
PMID:6428401
Abstract

N beta- fumarylcarboxyamido -L-2,3-diaminopropionic acid ( FCDP ), a novel glutamine analog, inhibits the reaction of glucosamine-6-phosphate synthetase (EC 5.3.1.19) from Salmonella typhimurium LT 2 by irreversible inactivation of the enzyme. The kinetic data on enzyme inhibition and inactivation are presented. It is suggested that the enzyme inactivation occurs according to a sequential mechanism.

摘要

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