Garcia M R, Ryan N D, Rabinovitch H, Ambrosini P, Twomey J, Iyengar S, Novacenko H, Nelson B, Puig-Antich J
University of California, San Diego.
J Am Acad Child Adolesc Psychiatry. 1991 May;30(3):398-406. doi: 10.1097/00004583-199105000-00008.
In an effort to evaluate whether differences exist in the hypothalamic-pituitary-thyroid axis of depressed children, a thyrotropin releasing hormone (TRH) stimulation test was administered to 55 prepubertal subjects who were divided into three groups matched for age and sex: a depressed group (endogenous N = 15, nonendogenous N = 15), a psychiatric nondepressed control group (N = 16), and a normal control group (N = 9). Each subject was tested at two dosages of TRH, 2 micrograms/kg and 7 micrograms/kg. Increasing age and female sex were positively correlated with a greater thyroid stimulating hormone (TSH) response. TSH response to TRH was examined with subjects reclassified by severe suicidal ideation, severe aggression, and parental history of alcoholism. Results of this study are contrasted with the adult psychiatric literature.
为了评估抑郁儿童的下丘脑 - 垂体 - 甲状腺轴是否存在差异，对55名青春期前受试者进行了促甲状腺激素释放激素（TRH）刺激试验，这些受试者按年龄和性别分为三组：抑郁组（内源性抑郁N = 15，非内源性抑郁N = 15）、精神科非抑郁对照组（N = 16）和正常对照组（N = 9）。每位受试者接受了两种剂量的TRH测试，分别为2微克/千克和7微克/千克。年龄增长和女性性别与更大的促甲状腺激素（TSH）反应呈正相关。根据严重自杀意念、严重攻击行为和酗酒家族史对受试者进行重新分类后，对TSH对TRH的反应进行了检查。本研究结果与成人精神科文献进行了对比。
